mTOR inhibition mitigates enhanced mRNA translation associated with the metastatic phenotype of osteosarcoma cells in vivo

PURPOSE: To successfully metastasize, tumor cells must respond appropriately to biological stressors encountered during metastatic progression. We sought to test the hypothesis that enhanced efficiency of mRNA translation during periods of metastatic stress is required for metastatic competence of o...

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Publicado no:Clin Cancer Res
Main Authors: Morrow, James J., Mendoza, Arnulfo, Koyen, Allyson, Lizardo, Michael M., Ren, Ling, Waybright, Timothy J., Hansen, Ryan J., Gustafson, Daniel L., Zhou, Ming, Fan, Timothy M., Scacheri, Peter C., Khanna, Chand
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161706/
https://ncbi.nlm.nih.gov/pubmed/27342399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0326
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