A computationally engineered RAS rheostat reveals RAS/ERK signaling dynamics

Synthetic protein switches controlled with user-defined inputs are powerful tools for studying and controlling dynamic cellular processes. To date, these approaches have relied primarily on intermolecular regulation. Here, we report a computationally-guided framework for engineering intramolecular r...

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Foilsithe in:Nat Chem Biol
Main Authors: Rose, John C., Huang, Po-Ssu, Camp, Nathan D., Ye, Jordan, Leidal, Andrew M., Goreshnik, Inna, Trevillian, Bridget M., Dickinson, Miles S., Cunningham-Bryant, Daniel, Debnath, Jayanta, Baker, David, Wolf-Yadlin, Alejandro, Maly, Dustin J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161653/
https://ncbi.nlm.nih.gov/pubmed/27870838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2244
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