Inhibiting the SUMO Pathway Represses the Cancer Stem Cell Population in Breast and Colorectal Carcinomas

Many solid cancers have an expanded CD44(+/hi)/CD24(−/low) cancer stem cell (CSC) population, which are relatively chemoresistant and drive recurrence and metastasis. Achieving a more durable response requires the development of therapies that specifically target CSCs. Recent evidence indicated that...

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Publicado no:Stem Cell Reports
Main Authors: Bogachek, Maria V., Park, Jung M., De Andrade, James P., Lorenzen, Allison W., Kulak, Mikhail V., White, Jeffrey R., Gu, Vivian W., Wu, Vincent T., Weigel, Ronald J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161532/
https://ncbi.nlm.nih.gov/pubmed/27916539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.11.001
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