In Vitro Models of GJB2-Related Hearing Loss Recapitulate Ca(2+) Transients via a Gap Junction Characteristic of Developing Cochlea

Mutation of the Gap Junction Beta 2 gene (GJB2) encoding connexin 26 (CX26) is the most frequent cause of hereditary deafness worldwide and accounts for up to 50% of non-syndromic sensorineural hearing loss cases in some populations. Therefore, cochlear CX26-gap junction plaque (GJP)-forming cells s...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Fukunaga, Ichiro, Fujimoto, Ayumi, Hatakeyama, Kaori, Aoki, Toru, Nishikawa, Atena, Noda, Tetsuo, Minowa, Osamu, Kurebayashi, Nagomi, Ikeda, Katsuhisa, Kamiya, Kazusaku
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161531/
https://ncbi.nlm.nih.gov/pubmed/27840044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2016.10.005
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