Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo

The accumulation of N-retinylidene-N-retinylethanolamine (A2E, a toxic by-product of the visual pigment cycle) in the retinal pigment epithelium (RPE) is a major cause of visual impairment in the elderly. Photooxidation of A2E results in retinal pigment epithelium degeneration followed by that of as...

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Publicado en:PLoS One
Main Authors: Fontaine, Valérie, Monteiro, Elodie, Brazhnikova, Elena, Lesage, Laëtitia, Balducci, Christine, Guibout, Louis, Feraille, Laurence, Elena, Pierre-Paul, Sahel, José-Alain, Veillet, Stanislas, Lafont, René
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161507/
https://ncbi.nlm.nih.gov/pubmed/27992460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167793
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