Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons

BACKGROUND: Disseminated or fatal Zika virus (ZIKV) infections were reported in immunosuppressed patients. Existing interferon-signaling/receptor-deficient mouse models may not be suitable for evaluating treatment effects of recombinant interferons. METHODS: We developed a novel mouse model for ZIKV...

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Publicado en:EBioMedicine
Autores principales: Chan, Jasper Fuk-Woo, Zhang, Anna Jinxia, Chan, Chris Chung-Sing, Yip, Cyril Chik-Yan, Mak, Winger Wing-Nga, Zhu, Houshun, Poon, Vincent Kwok-Man, Tee, Kah-Meng, Zhu, Zheng, Cai, Jian-Piao, Tsang, Jessica Oi-Ling, Chik, Kenn Ka-Heng, Yin, Feifei, Chan, Kwok-Hung, Kok, Kin-Hang, Jin, Dong-Yan, Au-Yeung, Rex Kwok-Him, Yuen, Kwok-Yung
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161441/
https://ncbi.nlm.nih.gov/pubmed/27884655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.11.017
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