Urinary Podocyte Loss Is Increased in Patients with Fabry Disease and Correlates with Clinical Severity of Fabry Nephropathy

Chronic kidney disease is a major complication of Fabry disease. Podocytes accumulate globotriaosylceramide inclusions more than other kidney cell types in Fabry patients. Podocyte injury occurs early in age, and is progressive. Since injured podocytes detach into the urine (podocyturia), we hypothe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fall, Brent, Scott, C. Ronald, Mauer, Michael, Shankland, Stuart, Pippin, Jeffrey, Jefferson, Jonathan A., Wallace, Eric, Warnock, David, Najafian, Behzad
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161377/
https://ncbi.nlm.nih.gov/pubmed/27992580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168346
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