Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle

Duchenne muscular dystrophy (DMD) is a devastating muscle disease characterized by progressive muscle deterioration and replacement with an aberrant fatty, fibrous matrix. Chronic upregulation of nuclear factor κB (NF-κB) is implicated as a driver of the dystrophic pathogenesis. Herein, 2 members of...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Hammers, David W., Sleeper, Margaret M., Forbes, Sean C., Coker, Cora C., Jirousek, Michael R., Zimmer, Michael, Walter, Glenn A., Sweeney, H. Lee
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161210/
https://ncbi.nlm.nih.gov/pubmed/28018975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90341
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