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Tumors smother their epigenome

DNA hypermethylation is pervasive in tumors, but the factors triggering this modification are largely unknown. We recently demonstrated that the activity of 10-11-translocation methylcytosine dioxygenases, initiators of DNA demethylation, is compromised in hypoxic tumors. The resultant accumulation...

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Bibliografske podrobnosti
izdano v:Mol Cell Oncol
Main Authors: Thienpont, Bernard, Van Dyck, Laurien, Lambrechts, Diether
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5160384/
https://ncbi.nlm.nih.gov/pubmed/28090580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1240549
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