Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

BACKGROUND: STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead to cell death. We tested whether an integrin-FAK-STAT3 signaling pathway we rece...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Commun Signal
Prif Awduron: Visavadiya, Nishant P., Keasey, Matthew P., Razskazovskiy, Vladislav, Banerjee, Kalpita, Jia, Cuihong, Lovins, Chiharu, Wright, Gary L., Hagg, Theo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159999/
https://ncbi.nlm.nih.gov/pubmed/27978828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-016-0157-7
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