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Nucleotide-free kinesin motor domains reversibly convert to an inactive conformation with characteristics of a molten globule

Nucleotide-free kinesin motor domains from several kinesin families convert reversibly to a refractory conformation that cannot rapidly rebind ADP. In the absence of glycerol, the refractory conformation of Drosophila kinesin motor domains is favored by 50-fold with conversion of the active to the r...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Hackney, David D., McGoff, Marshall
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159748/
https://ncbi.nlm.nih.gov/pubmed/27576140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.08.019
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