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Type I interferon causes thrombotic microangiopathy by a dose-dependent toxic effect on the microvasculature

Many drugs have been reported to cause thrombotic microangiopathy (TMA), yet evidence supporting a direct association is often weak. In particular, TMA has been reported in association with recombinant type I interferon (IFN) therapies, with recent concern regarding the use of IFN in multiple sclero...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Kavanagh, David, McGlasson, Sarah, Jury, Alexa, Williams, Jac, Scolding, Neil, Bellamy, Chris, Gunther, Claudia, Ritchie, Diane, Gale, Daniel P., Kanwar, Yashpal S., Challis, Rachel, Buist, Holly, Overell, James, Weller, Belinda, Flossmann, Oliver, Blunden, Mark, Meyer, Eric P., Krucker, Thomas, Evans, Stephen J. W., Campbell, Iain L., Jackson, Andrew P., Chandran, Siddharthan, Hunt, David P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159705/
https://ncbi.nlm.nih.gov/pubmed/27663672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-715987
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