The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue

Noncanonical mechanistic target of rapamycin (mTOR) pathways remain poorly understood. Mutations in the tumor suppressor folliculin (FLCN) cause Birt-Hogg-Dubé syndrome, a hamartomatous disease marked by mitochondria-rich kidney tumors. FLCN functionally interacts with mTOR and is expressed in most...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Wada, Shogo, Neinast, Michael, Jang, Cholsoon, Ibrahim, Yasir H., Lee, Gina, Babu, Apoorva, Li, Jian, Hoshino, Atsushi, Rowe, Glenn C., Rhee, James, Martina, José A., Puertollano, Rosa, Blenis, John, Morley, Michael, Baur, Joseph A., Seale, Patrick, Arany, Zoltan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159669/
https://ncbi.nlm.nih.gov/pubmed/27913603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.287953.116
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