A deafness-associated tRNA(Asp) mutation alters the m(1)G37 modification, aminoacylation and stability of tRNA(Asp) and mitochondrial function

In this report, we investigated the pathogenic mechanism underlying the deafness-associated mitochondrial(mt) tRNA(Asp) 7551A > G mutation. The m.7551A > G mutation is localized at a highly conserved nucleotide(A37), adjacent (3′) to the anticodon, which is important for the fidelity of codon...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nucleic Acids Res
Egile Nagusiak: Wang, Meng, Peng, Yanyan, Zheng, Jing, Zheng, Binjiao, Jin, Xiaofen, Liu, Hao, Wang, Yong, Tang, Xiaowen, Huang, Taosheng, Jiang, Pingping, Guan, Min-Xin
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2016
Gaiak:
RNA
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159531/
https://ncbi.nlm.nih.gov/pubmed/27536005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw726
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