A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

To cause disease, a microbial pathogen must adapt to the challenges of its host environment. The leading fungal pathogen Candida albicans colonizes nutrient-poor bodily niches, withstands attack from the immune system, and tolerates treatment with azole antifungals, often evolving resistance. To dis...

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Опубликовано в: :Cell Chem Biol
Главные авторы: Vincent, Benjamin M., Langlois, Jean-Baptiste, Srinivas, Raja, Lancaster, Alex K., Scherz-Shouval, Ruth, Whitesell, Luke, Tidor, Bruce, Buchwald, Stephen L., Lindquist, Susan
Формат: Artigo
Язык:Inglês
Опубликовано: 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5159300/
https://ncbi.nlm.nih.gov/pubmed/27524297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.06.016
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