Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

Cytomegalovirus (CMV) elicits long-term T-cell immunity of unparalleled strength, which has allowed the development of highly protective CMV-based vaccine vectors. Counterintuitively, experimental vaccines encoding a single MHC-I restricted epitope offered better immune protection than those express...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Dekhtiarenko, Iryna, Ratts, Robert B., Blatnik, Renata, Lee, Lian N., Fischer, Sonja, Borkner, Lisa, Oduro, Jennifer D., Marandu, Thomas F., Hoppe, Stephanie, Ruzsics, Zsolt, Sonnemann, Julia K., Mansouri, Mandana, Meyer, Christine, Lemmermann, Niels A. W., Holtappels, Rafaela, Arens, Ramon, Klenerman, Paul, Früh, Klaus, Reddehase, Matthias J., Riemer, Angelika B., Cicin-Sain, Luka
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5158087/
https://ncbi.nlm.nih.gov/pubmed/27977791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006072
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