Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells

BACKGROUND: The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. The α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed to investigate the regulation of...

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Veröffentlicht in:PLoS One
Hauptverfasser: Okagawa, Yutaka, Takada, Kohichi, Arihara, Yohei, Kikuchi, Shohei, Osuga, Takahiro, Nakamura, Hajime, Kamihara, Yusuke, Hayasaka, Naotaka, Usami, Makoto, Murase, Kazuyuki, Miyanishi, Koji, Kobune, Masayoshi, Kato, Junji
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5158067/
https://ncbi.nlm.nih.gov/pubmed/27977808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168355
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