AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue

Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake i...

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Udgivet i:Cell
Main Authors: Steculorum, Sophie M., Ruud, Johan, Karakasilioti, Ismene, Backes, Heiko, Ruud, Linda Engström, Timper, Katharina, Hess, Martin E., Tsaousidou, Eva, Mauer, Jan, Vogt, Merly C., Paeger, Lars, Bremser, Stephan, Klein, Andreas C., Morgan, Donald A., Frommolt, Peter, Brinkkötter, Paul T., Hammerschmidt, Philipp, Benzing, Thomas, Rahmouni, Kamal, Wunderlich, F. Thomas, Kloppenburg, Peter, Brüning, Jens C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157157/
https://ncbi.nlm.nih.gov/pubmed/27015310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.044
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