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Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation
The epigenetic processes that regulate antibody secreting plasma cells are not well understood. Here, analysis of plasma cell differentiation revealed DNA hypomethylation of 10% of CpG loci that were overrepresented at enhancers. Inhibition of DNA methylation enhanced plasma cell commitment in a cel...
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| Publié dans: | Nat Immunol |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5157049/ https://ncbi.nlm.nih.gov/pubmed/27500631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3519 |
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