Biological characteristics comparison of HBV rtA181T mutants with truncated or substituted HBsAg expression in vitro and in vivo model systems

The hepatitis B virus(HBV) polymerase rtA181T mutation is selected during long-term antiviral therapy. As the polymerase gene completely overlaps with the envelope (S) gene, HBV rtA181T mutation also carries sW172 mutations. In this study, we investigated whether there were biological differences be...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Zhou, Ling-Yun, Chen, En-Qiang, Wang, Meng-Lan, Chen, Lan-Lan, Liu, Cui-Ping, Zeng, Fan, Tang, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157016/
https://ncbi.nlm.nih.gov/pubmed/27976732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39260
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