Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Epothilones have demonstrated promising potential for oncology applications but suffer from a narrow therapeutic window. Epothilone D stabilizes microtubules leading to apoptosis, is active against multidrug-resistant cells, and is efficacious in animal tumor models despite lack of stability in rode...

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Detalhes bibliográficos
Publicado no:J Drug Deliv
Main Authors: Carie, Adam, Sullivan, Bradford, Ellis, Tyler, Semple, J. Edward, Buley, Taylor, Costich, Tara Lee, Crouse, Richard, Bakewell, Suzanne, Sill, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156807/
https://ncbi.nlm.nih.gov/pubmed/28044108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/8046739
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