Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

Recent studies have generated interest in the function of human adenovirus serotype 5 (HAdV-5) hexon:  factor X (FX) binding and subsequent hepatocyte transduction and interaction with the immune system. Here, we retargeted adenovirus serotype 5 vectors, ablated for FX interaction, by replacing amin...

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Detalhes bibliográficos
Publicado no:J Gen Virol
Main Authors: Robertson, Stacy, Parker, Alan L., Clarke, Carolyn, Duffy, Margaret R., Alba, Raul, Nicklin, Stuart A., Baker, Andrew H.
Formato: Artigo
Idioma:Inglês
Publicado em: Microbiology Society 2016
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156330/
https://ncbi.nlm.nih.gov/pubmed/27189759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1099/jgv.0.000505
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