Staphylococcus aureus Leukocidin LukED and HIV-1 gp120 Target Different Sequence Determinants on CCR5

Leukocidin ED (LukED) is a bicomponent pore-forming toxin produced by Staphylococcus aureus that lyses host cells by targeting the chemokine receptors CC chemokine receptor type 5 (CCR5), CXCR1, CXCR2, and DARC. In addition to its role as a receptor for LukED, CCR5 is the major coreceptor for primar...

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Bibliographic Details
Published in:mBio
Main Authors: Tam, Kayan, Schultz, Megan, Reyes-Robles, Tamara, Vanwalscappel, Bénédicte, Horton, Joshua, Alonzo, Francis, Wu, Beili, Landau, Nathaniel R., Torres, Victor J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156306/
https://ncbi.nlm.nih.gov/pubmed/27965453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02024-16
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