The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment

Alpaca-derived single-domain antibody fragments (VHHs) that target the influenza A virus nucleoprotein (NP) can protect cells from infection when expressed in the cytosol. We found that one such VHH, αNP-VHH1, exhibits antiviral activity similar to that of Mx proteins by blocking nuclear import of i...

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Publicat a:mBio
Autors principals: Hanke, Leo, Knockenhauer, Kevin E., Brewer, R. Camille, van Diest, Eline, Schmidt, Florian I., Schwartz, Thomas U., Ploegh, Hidde L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2016
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5156300/
https://ncbi.nlm.nih.gov/pubmed/27965447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01569-16
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