Multivalent pIX phage display selects for distinct and improved antibody properties

Phage display screening readily allows for the identification of a multitude of antibody specificities, but to identify optimal lead candidates remains a challenge. Here, we direct the antibody-capsid fusion away from the signal sequence-dependent secretory SEC pathway in E. coli by utilizing the in...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Høydahl, Lene S., Nilssen, Nicolay R., Gunnarsen, Kristin S., Pré, M. Fleur du, Iversen, Rasmus, Roos, Norbert, Chen, Xi, Michaelsen, Terje E., Sollid, Ludvig M., Sandlie, Inger, Løset, Geir Å.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155289/
https://ncbi.nlm.nih.gov/pubmed/27966617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep39066
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