Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

In vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of human embryogenesis, but the underlying processes are poorly understood and controlled. Here we show that modulating the bulk cell density (BCD: cell number per culture volume) deterministically alters an...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kempf, Henning, Olmer, Ruth, Haase, Alexandra, Franke, Annika, Bolesani, Emiliano, Schwanke, Kristin, Robles-Diaz, Diana, Coffee, Michelle, Göhring, Gudrun, Dräger, Gerald, Pötz, Oliver, Joos, Thomas, Martinez-Hackert, Erik, Haverich, Axel, Buettner, Falk F. R., Martin, Ulrich, Zweigerdt, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155150/
https://ncbi.nlm.nih.gov/pubmed/27934856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13602
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