Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

Ageing is a natural process in living organisms throughout their lifetime, and most elderly people suffer from ageing-associated diseases. One suggested way to tackle such diseases is to rejuvenate stem cells, which also undergo ageing. Here we report that the thioredoxin-interacting protein (TXNIP)...

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Udgivet i:Nat Commun
Main Authors: Jung, Haiyoung, Kim, Dong Oh, Byun, Jae-Eun, Kim, Won Sam, Kim, Mi Jeong, Song, Hae Young, Kim, Young Kwan, Kang, Du-Kyeong, Park, Young-Jun, Kim, Tae-Don, Yoon, Suk Ran, Lee, Hee Gu, Choi, Eun-Ji, Min, Sang-Hyun, Choi, Inpyo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5155146/
https://ncbi.nlm.nih.gov/pubmed/27929088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13674
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