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Genetics of Gigantism and Acromegaly

Gigantism and acromegaly are rare disorders that are caused by excessive GH secretion and/or high levels of its mediator, IGF-1. Gigantism occurs when excess GH or IGF-1 lead to increased linear growth, before the end of puberty and epiphyseal closure. The majority of cases arise from a benign GH-se...

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Detalhes bibliográficos
Publicado no:Growth Horm IGF Res
Main Authors: Hannah-Shmouni, Fady, Trivellin, Giampaolo, Stratakis, Constantine A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154831/
https://ncbi.nlm.nih.gov/pubmed/27657986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ghir.2016.08.002
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