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Toll-interacting protein deficiency promotes neurodegeneration via impeding autophagy completion in high-fat diet-fed ApoE(−/−) mouse model

The excessive accumulation of specific cellular proteins or autophagic vacuoles (AVs) within neurons is a pathologic hallmark of neurodegenerative diseases. Constitutive autophagy in neurons prevents abnormal intracellular protein aggregation and is critical for maintaining cell survival. Since our...

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Detalhes bibliográficos
Publicado no:Brain Behav Immun
Main Authors: Chen, Keqiang, Yuan, Ruoxi, Geng, Shuo, Zhang, Yao, Ran, Taojing, Kowalski, Elizabeth, Liu, Jingze, Li, Liwu
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154796/
https://ncbi.nlm.nih.gov/pubmed/27720815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2016.10.002
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