X-Linked Alport Dogs Demonstrate Mesangial Filopodial Invasion of the Capillary Tuft as an Early Event in Glomerular Damage

BACKGROUND: X-linked Alport syndrome (XLAS), caused by mutations in the type IV collagen COL4A5 gene, accounts for approximately 80% of human Alport syndrome. Dogs with XLAS have a similar clinical progression. Prior studies in autosomal recessive Alport mice demonstrated early mesangial cell invasi...

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Udgivet i:PLoS One
Main Authors: Clark, Sabrina D., Nabity, Mary B., Cianciolo, Rachel E., Dufek, Brianna, Cosgrove, Dominic
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154607/
https://ncbi.nlm.nih.gov/pubmed/27959966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168343
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