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Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation
Ubiquitin fusion degradation (UFD) substrates are delivered at the proteasome by a handover mechanism involving the ubiquitin-selective chaperone Cdc48 and the ubiquitin shuttle factor Rad23. Here, we show that introduction of a 20 amino acid peptide extension not only rendered degradation independe...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5154593/ https://ncbi.nlm.nih.gov/pubmed/25556859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07615 |
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