Therapeutic Potential of Immunoproteasome Inhibition in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy is an inherited fatal genetic disease characterized by mutations in dystrophin gene, causing membrane fragility leading to myofiber necrosis and inflammatory cell recruitment in dystrophic muscles. The resulting environment enriched in proinflammatory cytokines, like IFN-...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Farini, Andrea, Sitzia, Clementina, Cassani, Barbara, Cassinelli, Letizia, Rigoni, Rosita, Colleoni, Federica, Fusco, Nicola, Gatti, Stefano, Bella, Pamela, Villa, Chiara, Napolitano, Filomena, Maiavacca, Rita, Bosari, Silvano, Villa, Anna, Torrente, Yvan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154478/
https://ncbi.nlm.nih.gov/pubmed/27506451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.162
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