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Therapeutic Potential of Immunoproteasome Inhibition in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy is an inherited fatal genetic disease characterized by mutations in dystrophin gene, causing membrane fragility leading to myofiber necrosis and inflammatory cell recruitment in dystrophic muscles. The resulting environment enriched in proinflammatory cytokines, like IFN-...
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| Veröffentlicht in: | Mol Ther |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5154478/ https://ncbi.nlm.nih.gov/pubmed/27506451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.162 |
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