Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques

The design of an effective HIV-1 vaccine remains a major challenge. Several vaccine strategies based on viral vectors have been evaluated in preclinical and clinical trials, with largely disappointing results. Integrase defective lentiviral vectors (IDLV) represent a promising vaccine candidate give...

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Publicat a:Mol Ther
Autors principals: Negri, Donatella, Blasi, Maria, LaBranche, Celia, Parks, Robert, Balachandran, Harikrishnan, Lifton, Michelle, Shen, Xiaoying, Denny, Thomas, Ferrari, Guido, Vescio, Maria Fenicia, Andersen, Hanne, Montefiori, David C, Tomaras, Georgia D, Liao, Hua-Xin, Santra, Sampa, Haynes, Barton F, Klotman, Mary E, Cara, Andrea
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154473/
https://ncbi.nlm.nih.gov/pubmed/27455880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.123
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