Pressure-induced oxidative activation of PKG enables vasoregulation by Ca(2+) sparks and BK channels

Activation of Ca(2+)-sensitive, large-conductance potassium (BK) channels in vascular smooth muscle cells (VSMCs) by local, ryanodine receptor-mediated Ca(2+) signals (Ca(2+) sparks) acts as a brake on pressure-induced (myogenic) vasoconstriction—a fundamental mechanism that regulates blood flow in...

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Veröffentlicht in:Sci Signal
Hauptverfasser: Khavandi, Kaivan, Baylie, Rachael A., Sugden, Sarah A., Ahmed, Majid, Csato, Viktoria, Eaton, Philip, Hill-Eubanks, David C., Bonev, Adrian D., Nelson, Mark T., Greenstein, Adam S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154376/
https://ncbi.nlm.nih.gov/pubmed/27729550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaf6625
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