A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

Previous studies have shown that biological noise may drive dynamic phenotypic mosaicism in isogenic unicellular organisms. However, there is no evidence for a similar mechanism operating in metazoans. Here we show that the endothelial-restricted gene, von Willebrand factor (VWF), is expressed in a...

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Udgivet i:Nat Commun
Main Authors: Yuan, Lei, Chan, Gary C., Beeler, David, Janes, Lauren, Spokes, Katherine C., Dharaneeswaran, Harita, Mojiri, Anahita, Adams, William J., Sciuto, Tracey, Garcia-Cardeña, Guillermo, Molema, Grietje, Kang, Peter M., Jahroudi, Nadia, Marsden, Philip A., Dvorak, Ann, Regan, Erzsébet Ravasz, Aird, William C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154372/
https://ncbi.nlm.nih.gov/pubmed/26744078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10160
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