A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

Previous studies have shown that biological noise may drive dynamic phenotypic mosaicism in isogenic unicellular organisms. However, there is no evidence for a similar mechanism operating in metazoans. Here we show that the endothelial-restricted gene, von Willebrand factor (VWF), is expressed in a...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yuan, Lei, Chan, Gary C., Beeler, David, Janes, Lauren, Spokes, Katherine C., Dharaneeswaran, Harita, Mojiri, Anahita, Adams, William J., Sciuto, Tracey, Garcia-Cardeña, Guillermo, Molema, Grietje, Kang, Peter M., Jahroudi, Nadia, Marsden, Philip A., Dvorak, Ann, Regan, Erzsébet Ravasz, Aird, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154372/
https://ncbi.nlm.nih.gov/pubmed/26744078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10160
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