Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins

Multiple myeloma arises when malignant plasma cells invade and form multiple tumors in the bone marrow. High levels of heparanase (HPSE) correlate with poor prognosis in myeloma patients. A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly...

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Detalles Bibliográficos
Publicado en:Oncogenesis
Main Authors: Jung, O, Trapp-Stamborski, V, Purushothaman, A, Jin, H, Wang, H, Sanderson, R D, Rapraeger, A C
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154350/
https://ncbi.nlm.nih.gov/pubmed/26926788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2016.5
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