Rare and common epilepsies converge on a shared gene regulatory network providing opportunities for novel antiepileptic drug discovery

BACKGROUND: The relationship between monogenic and polygenic forms of epilepsy is poorly understood and the extent to which the genetic and acquired epilepsies share common pathways is unclear. Here, we use an integrated systems-level analysis of brain gene expression data to identify molecular netw...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Delahaye-Duriez, Andree, Srivastava, Prashant, Shkura, Kirill, Langley, Sarah R., Laaniste, Liisi, Moreno-Moral, Aida, Danis, Bénédicte, Mazzuferi, Manuela, Foerch, Patrik, Gazina, Elena V., Richards, Kay, Petrou, Steven, Kaminski, Rafal M., Petretto, Enrico, Johnson, Michael R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5154105/
https://ncbi.nlm.nih.gov/pubmed/27955713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1097-7
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