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Requirement for Pathogenic IL-23 Signaling Is Restricted to Initiation of Autoimmune Myocarditis
Using a mouse model of experimental autoimmune myocarditis (EAM), we showed for the first time that IL-23 stimulation of CD4(+) T cells is required only briefly at the initiation of GM-CFS-dependent cardiac autoimmunity. IL-23 signal, acting as a switch, turns on pathogenicity of CD4+ T cells, and b...
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| Izdano u: | Eur J Immunol |
|---|---|
| Glavni autori: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5153891/ https://ncbi.nlm.nih.gov/pubmed/26660726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201545924 |
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