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Engineering Aspergillus niger for galactaric acid production: elimination of galactaric acid catabolism by using RNA sequencing and CRISPR/Cas9

BACKGROUND: meso-Galactaric acid is a dicarboxylic acid that can be produced by the oxidation of d-galacturonic acid, the main constituent of pectin. Mould strains can be engineered to perform this oxidation by expressing the bacterial enzyme uronate dehydrogenase. In addition, the endogenous pathwa...

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Foilsithe in:Microb Cell Fact
Main Authors: Kuivanen, Joosu, Wang, Y.-M. Jasmin, Richard, Peter
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153877/
https://ncbi.nlm.nih.gov/pubmed/27955649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-016-0613-5
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