A Drosophila Pattern Recognition Receptor Contains a Peptidoglycan Docking Groove and Unusual L,D-Carboxypeptidase Activity

The Drosophila peptidoglycan recognition protein SA (PGRP-SA) is critically involved in sensing bacterial infection and activating the Toll signaling pathway, which induces the expression of specific antimicrobial peptide genes. We have determined the crystal structure of PGRP-SA to 2.2-Å resolution...

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Bibliografiske detaljer
Main Authors: Chang, Chung-I, Pili-Floury, Sébastien, Hervé, Mireille, Parquet, Claudine, Chelliah, Yogarany, Lemaitre, Bruno, Mengin-Lecreulx, Dominique, Deisenhofer, Johann
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC515366/
https://ncbi.nlm.nih.gov/pubmed/15361936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020277
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