Autocrine Extracellular Signal-regulated Kinase (ERK) Activation in Normal Human Keratinocytes: Metalloproteinase-mediated Release of Amphiregulin Triggers Signaling from ErbB1 to ERK

ErbB signaling through extracellular signal-regulated kinase (ERK) has been implicated in regulating the expression of ErbB ligands in hyperproliferative skin disorders and wound healing. Here, we characterize the process of autocrine ERK activation in cultured normal human keratinocytes (NHKs) subj...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Kansra, Sanjay, Stoll, Stefan W., Johnson, Jessica L., Elder, James T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Cell Biology 2004
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Articles
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC515360/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15254267/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.E04-03-0233
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