Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma

Epidemiological studies showed that obesity and its related non-alcoholic fatty liver disease (NAFLD) promote hepatocellular carcinoma (HCC) development. We aimed to uncover the genetic alterations of NAFLD-HCC using whole-exome sequencing. We compared HCC development in genetically obese mice and d...

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Vydáno v:Oncogene
Hlavní autoři: Shen, J, Tsoi, H, Liang, Q, Chu, E S H, Liu, D, Yu, A C-S, Chan, T F, Li, X, Sung, J J Y, Wong, V W S, Yu, J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153568/
https://ncbi.nlm.nih.gov/pubmed/27132506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.162
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