Endogenous Retrotransposition Activates Oncogenic Pathways in Hepatocellular Carcinoma

LINE-1 (L1) retrotransposons are mobile genetic elements comprising ∼17% of the human genome. New L1 insertions can profoundly alter gene function and cause disease, though their significance in cancer remains unclear. Here, we applied enhanced retrotransposon capture sequencing (RC-seq) to 19 hepat...

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Bibliografische gegevens
Hoofdauteurs: Shukla, Ruchi, Upton, Kyle R., Muñoz-Lopez, Martin, Gerhardt, Daniel J., Fisher, Malcolm E., Nguyen, Thu, Brennan, Paul M., Baillie, J. Kenneth, Collino, Agnese, Ghisletti, Serena, Sinha, Shruti, Iannelli, Fabio, Radaelli, Enrico, Dos Santos, Alexandre, Rapoud, Delphine, Guettier, Catherine, Samuel, Didier, Natoli, Gioacchino, Carninci, Piero, Ciccarelli, Francesca D., Garcia-Perez, Jose Luis, Faivre, Jamila, Faulkner, Geoffrey J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3898742/
https://ncbi.nlm.nih.gov/pubmed/23540693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2013.02.032
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