Hepatocellular alterations and dysregulation of oncogenic pathways in the liver of transgenic mice overexpressing growth hormone

Growth hormone (GH) overexpression throughout life in transgenic mice is associated with the development of liver tumors at old ages. The preneoplastic pathology observed in the liver of young adult GH-overexpressing mice is similar to that present in humans at high risk of hepatic cancer. To elucid...

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Main Authors: Miquet, Johanna G., Freund, Thomas, Martinez, Carolina S., González, Lorena, Díaz, María E., Micucci, Giannina P., Zotta, Elsa, Boparai, Ravneet K., Bartke, Andrzej, Turyn, Daniel, Sotelo, Ana I.
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3646861/
https://ncbi.nlm.nih.gov/pubmed/23428905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.24026
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