Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex

Eukaryotic translation initiation factor 3 (eIF3) is a central player in recruitment of the pre-initiation complex (PIC) to mRNA. We probed the effects on mRNA recruitment of a library of S. cerevisiae eIF3 functional variants spanning its 5 essential subunits using an in vitro-reconstituted system....

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Aitken, Colin Echeverría, Beznosková, Petra, Vlčkova, Vladislava, Chiu, Wen-Ling, Zhou, Fujun, Valášek, Leoš Shivaya, Hinnebusch, Alan G, Lorsch, Jon R
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2016
Sujets:
Biochemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5153249/
https://ncbi.nlm.nih.gov/pubmed/27782884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20934
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