Hydroxycholesterol Levels in the Serum and Cerebrospinal Fluid of Patients with Neuromyelitis Optica Revealed by LC-Ag(+)CIS/MS/MS and LC-ESI/MS/MS with Picolinic Derivatization: Increased Levels and Association with Disability during Acute Attack

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system (CNS). Hydroxycholesterols (OHCs), metabolites of CNS cholesterol, are involved in diverse cellular responses to inflammation and demyelination, and may also be involved in the pathogenesis of NMO. We a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cha, Eunju, Lee, Kang Mi, Park, Ki Duk, Park, Kyung Seok, Lee, Kwang-Woo, Kim, Sung-Min, Lee, Jaeick
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152860/
https://ncbi.nlm.nih.gov/pubmed/27942009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167819
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