Isoaspartylation Appears to Trigger Small Cell Lung Cancer-Associated Autoimmunity against Neuronal Protein ELAVL4

Autoantibodies against SCLC-associated neuronal antigen ELAVL4 (HuD) have been linked to smaller tumors and improved survival, but the antigenic epitope and mechanism of autoimmunity have never been solved. We report that recombinant human ELAVL4 protein incubated under physiological conditions acqu...

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Veröffentlicht in:J Neuroimmunol
Hauptverfasser: Pulido, Mario A., DerHartunian, Meleeneh Kazarian, Qin, Zhenxia, Chung, Eric M., Kang, Diane S., Woodham, Andrew W., Tsou, Jeffrey A., Klooster, Rinse, Akbari, Omid, Wang, Lina, Kast, W. Martin, Liu, Stephen V., Verschuuren, Jan J.G.M., Aswad, Dana W., Laird-Offringa, Ite A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152694/
https://ncbi.nlm.nih.gov/pubmed/27725125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2016.09.002
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