Relationship between spontaneous γH2AX foci formation and progenitor functions in circulating hematopoietic stem and progenitor cells among atomic-bomb survivors

Accumulated DNA damage in hematopoietic stem cells is a primary mechanism of aging-associated dysfunction in human hematopoiesis. About 70 years ago, atomic-bomb (A-bomb) radiation induced DNA damage and functional decreases in the hematopoietic system of A-bomb survivors in a radiation dose-depende...

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Publicado no:Mutat Res Genet Toxicol Environ Mutagen
Main Authors: Kajimura, Junko, Kyoizumi, Seishi, Kubo, Yoshiko, Misumi, Munechika, Yoshida, Kengo, Hayashi, Tomonori, Imai, Kazue, Ohishi, Waka, Nakachi, Kei, Weng, Nan-ping, Young, Lauren F., Shieh, Jae-Hung, Moore, Malcolm A., van den Brink, Marcel R.M., Kusunoki, Yoichiro
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152679/
https://ncbi.nlm.nih.gov/pubmed/27169377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2016.04.006
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