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Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as anti-microRNA Therapies

Self-assembled polymer/porous silicon nanocomposites overcome intracellular and systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics. Porous silicon (PSi) is leveraged as a biodegradable scaffold with high drug cargo loading capacity. Functionalization w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Adv Mater
Hauptverfasser: Beavers, Kelsey R., Werfel, Thomas A., Shen, Tianwei, Kavanaugh, Taylor E., Kilchrist, Kameron V., Mares, Jeremy W., Fain, Joshua S., Wiese, Carrie B., Vickers, Kasey C., Weiss, Sharon M., Duvall, Craig L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5152671/
https://ncbi.nlm.nih.gov/pubmed/27383910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/adma.201601646
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